Trichology
Oral Agents
To inhibit hair damaging hormone circulation and to increase hair growth.
Hair loss is largely a genetically-influenced phenomena, with genes inherited from either parent being a dominant factor in determining whether, and when you will lose your hair. However, hair loss can also be blamed on the presence of the male hormone, testosterone, a chemical agent which acts on the genetically susceptible hair follicles in men and women, instigating degenerative changes and preventing the hairs from growing as well as they should.
Although the effect on hair by the presence of excess testosterone can be reduced, it is now known that men with male balding have an increased capacity to convert testosterone to the more potent androgen, di-hydrotestosterone, via increased activity of the chemical substance or enzyme (5 alpha reductase) responsible for this conversion; di-hydrotestosterone (DHT) is the hormone, therefore, that can damage hair follicles most, greatly influencing hair loss in men who are genetically sensitive to it.
The amount of circulating DHT is therefore directly related to the extent of hair loss in the male; in those with high levels of DHT, hair loss can be more severe and rapid.
In most men, the body makes DHT in increasing amounts, usually from the late 20’s onwards, gradually converting or miniaturising thick hair into fine ‘baby’ hair, particularly on the ‘crown area’ and ‘temple region’, leading to a typical male pattern baldness scenario – there are, however, counter measures that can be taken.
Of the two damaging chemical substances (5–alpha reductase enzymes), type I predominates in skin, including the scalp, whereas type II is present in scalp hair follicles – if one, or both of these can be restrained, the chances of preventing hair loss are intensified.
Things you need to know
Proscar
Proscar (Finasteride) is a medical oral therapy that can be used as a recognised treatment for men with male pattern hair loss (androgenetic alopecia) to prevent further erosion of their hair, and to increase hair growth; for young men, it can also be used to deter hair loss starting.
Proscar, when taken as a dosage comprising Finasteride 1mg,, is a type II 5-alpha reductase inhibitor, reducing circulating DHT sufficiently without lowering testosterone levels, to a point where there is no further influence on hair loss – when DHT levels are low, hair follicles can strengthen, and produce hair for longer.
Extensive clinical trials, and evidence from other countries where the drug has already been used, have shown dramatic success rates, with hair thinning having stopped in most men who have taken the 1 mg tablet daily for six months, and some two-thirds having found that their hair has began to grow back. Generally, three to six months of once daily treatment are required before evidence of stabilisation of hair loss can be expected.